| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 27/05/25 23:00 | FC Sao Paulo | CA Talleres | Group D | 2-1 |
| 27/05/25 23:30 | Club Libertad | Alianza Lima | Group D | 2-2 |
| 28/05/25 01:30 | River Plate | Universitario | Group B | 1-1 |
| 28/05/25 01:30 | Independiente del Valle | Barcelona SC | Group B | 2-1 |
| 28/05/25 01:30 | Botafogo | Universidad de Chile | Group A | 1-0 |
| 28/05/25 01:30 | Estudiantes de La Plata | Carabobo FC | Group A | 2-0 |
| 28/05/25 23:00 | Club Nacional de Football | Atlético Nacional | Group F | 1-0 |
| 28/05/25 23:00 | Internacional | Bahia BA | Group F | 2-1 |
| 29/05/25 01:30 | Palmeiras | Sporting Cristal | Group G | 6-0 |
| 29/05/25 01:30 | Club Bolívar | Club Cerro Porteno | Group G | 4-0 |
| 29/05/25 01:30 | Flamengo | Deportivo Tachira | Group C | 1-0 |
| 29/05/25 01:30 | LDU Quito | Central Cordoba | Group C | 3-0 |
| 29/05/25 23:00 | Club Atlético Peñarol | CA Velez Sarsfield | Group H | 0-0 |
| 29/05/25 23:00 | Club Olimpia | San Antonio Bulo Bulo | Group H | 4-0 |
| 30/05/25 01:30 | Racing Club | Fortaleza | Group E | 1-0 |
| 30/05/25 01:30 | Colo-Colo | Atlético Bucaramanga | Group E | 1-0 |